Variable length protein design.
Title: Variable length protein design.
DNr: Berzelius-2026-261
Project Type: LiU Berzelius
Principal Investigator: Benjamin Murrell <benjamin.murrell@ki.se>
Affiliation: Karolinska Institutet
Duration: 2026-09-26 – 2027-04-01
Classification: 10610
Keywords:

Abstract

Current protein design models require the length of the protein to be specified in advance. Recently, we developed a new flow matching framework, Branching Flows (https://arxiv.org/abs/2511.09465), that allows the number of elements in the flow state to change during design. This project will further explore variable length protein design using this and other approaches, training new models and performing benchmarks.