Title:	Automatic magnetic resonance brain volume measurements to assess the effect of minimised blood sample extraction on brain development in extremely preterm infants
DNr:	NAISS 2025/22-227
Project Type:	NAISS Small Compute
Principal Investigator:	Hickmat Hamie <hickmat.hamie@med.lu.se>
Affiliation:	Lunds universitet
Duration:	2025-02-14 – 2026-03-01
Classification:	30208
Keywords:

Abstract

“Less is more” (LIM) is an ongoing randomized control trial of extremely preterm infants (EPT) born prior to gestational week 27 in Stockholm, Gothenburg and Lund. The control group is subject to conventional blood extraction methods, whereas in the intervention group minimally invasive blood sample extraction methods are used. The primary endpoint of LIM is to study whether the intervention prevents or alleviates bronchopulmonary dysplasia, a major cause of morbidity in these neonates. Volumetric brain quantification and structural segmentation utilizing magnetic resonance imaging are secondary research aims in LIM. The imaging is performed at term equivalent age of around 40 gestational weeks. In medical imaging, segmentation is the demarcation of tissues of interest. It is for the purpose of segmentation that I wish to be allocated computer resoursces in order to perform my analyses, which are done in collaboration with Professor Rolf Heckemann at GU who laso uses Tetralith.