Title:	Neuromorphometric signatures of diseases affecting the brain
DNr:	NAISS 2025/22-8
Project Type:	NAISS Small Compute
Principal Investigator:	Rolf A Heckemann <rolf.heckemann@gu.se>
Affiliation:	Göteborgs universitet
Duration:	2025-01-07 – 2026-02-01
Classification:	20603
Homepage:	https://soundray.org/metrimorphics
Keywords:

Abstract

Various conditions -- brain diseases as well as systemic diseases -- affect the human brain's structural configuration. For each condition, this raises the question whether quantifying such changes through morphometric analysis of brain images can yield biomarkers for predicting diagnosis, disease progression, and therapy response. I have developed image segmentation software (MAPER and Pincram) that automatically determines morphometric quantities on magnetic resonance images of the brain. In several collaborations, clinicians acquire images as part of clinical studies and transmit them to me for analysis, generally with the goal of identifying imaging biomarkers that might be of interest in the context of the respective disease or clinical specialty. With this application, I seek an allocation of computation time to conduct processing of images from such collaboration studies. In addition, I am planning to continue carrying out research projects (master's projects and similar) for methodological assessment and improvement.