Title:	AlphaFold2 prediction of the virus-host interactome
DNr:	Berzelius-2024-405
Project Type:	LiU Berzelius
Principal Investigator:	Vasili Hauryliuk <vasili.hauryliuk@med.lu.se>
Affiliation:	Lunds universitet
Duration:	2024-11-01 – 2025-05-01
Classification:	30109
Homepage:	https://portal.research.lu.se/en/persons/vasili-hauryliuk
Keywords:

Abstract

In order to take over their bacterial host, viruses called bacteriophages have to enter the bacterial cell and take over the host molecular information processing machinery for their own benefit. Through its immune system, the bacterial host tries to resist this attack, while the phage fights back via counter defence systems. This warfare involves a multitude of molecular interactions. We are interested in predicting those interactions that occur at the protein level. Protein co-folding with AlphaFold-Multimer is a powerful approach for making these predictions, which we will validate experimentally. We have already predicted host-pathogen interactions with AlphaFold (eg see DOI 10.1016/j.chom.2024.05.003), and this project is to continue these efforts for further biological discoveries.