Neuromorphometric signatures of diseases affecting the brain
Title: Neuromorphometric signatures of diseases affecting the brain
DNr: NAISS 2024/23-69
Project Type: NAISS Small Storage
Principal Investigator: Rolf A Heckemann <>
Affiliation: Göteborgs universitet
Duration: 2024-02-01 – 2025-02-01
Classification: 20603


Various conditions -- brain diseases as well as systemic diseases -- affect the human brain's structural configuration. For each condition, this raises the question whether quantifying such changes through morphometric analysis of brain images can yield biomarkers for predicting diagnosis, disease progression, and therapy response. I have developed image segmentation software (MAPER and Pincram, featured in IVA's 100-list of 2020, that automatically determines morphometric quantities on magnetic resonance images of the brain. With this application, I seek an allocation of computation time and storage to conduct processing of images from several collaboration studies: CogThy (a controlled study of Graves' disease and its impact on the brain, PI Helena Filipsson-Nyström PhD, GU), Automated brain tissue classification on CT images (Dr. Michael Schöll), NeumRA (rheumatoid arthritis, an autoimmune condition of the synovial joints with secondary brain involvement; PI Prof. Maria Bokarewa, GU), Parkinson's disease (Rolf Heckemann). In addition, I am planning to carry out research projects (master's projects and similar) for methodological assessment and improvement. Among other image processing tasks, this will involve segmenting images of healthy volunteers from publicly available repositories (e.g. the Human Connectome Project) to obtain normative morphometric reference data.