ProteinSequenceGeneration
Title: ProteinSequenceGeneration
SNIC Project: Berzelius-2022-166
Project Type: LiU Berzelius
Principal Investigator: Tobias Karlsson <tobiaka@chalmers.se>
Affiliation: Chalmers tekniska högskola
Duration: 2022-09-01 – 2023-03-01
Classification: 10203
Homepage: https://psolsson.github.io/team
Keywords:

Abstract

PhD thesis work regarding development of generative, probabilistic models for protein sequences with application in protein and biologics design. More specifically, to devise a machine learned, computational framework for optimization and design of antibodies. The framework will leverage ideas from natural language processing, data from next-generation sequencing technologies and molecular simulations, as well as inductive biases from chemistry and physics.