Title: PROBE
DNr: LiU-compute-2022-8
Project Type: LiU Compute
Principal Investigator: Gustav Magnusson <>
Affiliation: Linköpings universitet
Duration: 2022-03-23 – 2025-04-01
Classification: 20603


We aim at doing MR-imaging studies of subarachnoid hemorrhage patients in order to assess microvasculature physiology and pathology in the brain with the hope to enable earlier predictions of secondary complications such as delayed cerebral ischemia. Our main method of interest that we want do evaluate is measurement of the cerebrovascular reactivity using carbon dioxide provocation. By giving patients a controlled amount of carbon dioxide, we can provoke a dilation of the blood vessels and the following increase in blood flow can then be measured using various MRI techniques. We are planning to use the Blood Oxygen Level Dependent (BOLD) signal. From these measurements we are able to create maps of the blood vessels reactivity which we believe will have diagnostic power of vascular health and function for subarachnoid hemorrhage patients. We are also planning to estimate the changes in the brain by mechanistic mathematical modeling in order to deepen our understanding of the pathophysiology following a subarachnoid hemorrhage. The methods developed has direct clinical application and we have a close collaboration with the physicians at Linköping Hospital neurointensive care unit (NIVA) where the patients included in the study are being treated. Thanks to the newly installed intra-operative MRI scanner at NIVA, we have a unique opportunity of doing MRI studies on this patient group.