Molecular Modelling of Type IV Major Pilin Protein PilA Variants
||Molecular Modelling of Type IV Major Pilin Protein PilA Variants|
||SNIC Small Compute|
||Esra Bozkurt <firstname.lastname@example.org>|
||2021-08-18 – 2022-09-01|
Type IVa pili are ubiquitous and versatile bacterial cell surface filaments that undergo cycles of extension, adhesion and retraction. They represent significant mechanisms of environmental survival and pathogenesis. Since adhesion and twitching motility play important roles in pathogenicity, understanding structure/function relationships is vital for the development of innovative therapeutic strategies to combat infection.
Here we will explore the structure of two different PilA proteins (13 and 10 kDa, as a monomer) using molecular dynamics simulations. Our results should provide detailed insights into the conformational behaviour of two distinct PilA variants.