Epigenetic changes in the immune system during exposure to mycobacteria
Title: Epigenetic changes in the immune system during exposure to mycobacteria
SNIC Project: SNIC 2020/5-507
Project Type: SNIC Medium Compute
Principal Investigator: Maria Lerm <maria.lerm@liu.se>
Affiliation: Linköpings universitet
Duration: 2020-10-13 – 2021-11-01
Classification: 30109 30110 30107
Homepage: https://liu.se/medarbetare/marle69
Keywords:

Abstract

Tuberculosis (TB) is a disease of global importance and we follow a line of investigation in which we map epigenetic changes in response to exposure to the bacteria that cause TB or the TB vaccine, which is an attenuated mycobacterium. We are collecting informaiton on the DNA methylome using next generation sequencing techniques, generating large datasets. Our ambition is to identify patterns, or biosignatures, in the DNA methylome of immune cells, that reflect epigenetic changes during exposure to Mycobacterium tuberculosis or other mycobacteria. We need access to the supercomputer in order to perform parallel computation using machine learning approaches.