Cryo-EM study of GPCR related to Cancer
Title: Cryo-EM study of GPCR related to Cancer
DNr: Berzelius-2024-215
Project Type: LiU Berzelius
Principal Investigator: Simon Lind <>
Affiliation: Göteborgs universitet
Duration: 2024-05-21 – 2024-12-01
Classification: 10601


Cryo-EM is a powerful technique that allows for the determination of the three-dimensional structure of macromolecules, including GPCRs. There are many structures of GPCR in various conformations, the inactive state, the active state, and the intermediate states along the activation pathway, that are solved by cryo-EM. The project aims to determine the structure of an both an active and inactive GPCR with ligands using cryo-EM. This receptor is thought to be involved with cancer and inflammatory diseases. We did data collection at the SciLifeLab Cryo-EM facility and will hopefully use Cryosparc and Relion through the PreSTO program to process the data.