InfraLife integrative structural biology course 2022
Title: InfraLife integrative structural biology course 2022
SNIC Project: Berzelius-2022-123
Project Type: LiU Berzelius
Principal Investigator: Maria Josefin Lundgren Gawell <mjlg2@kth.se>
Affiliation: Kungliga Tekniska högskolan
Duration: 2022-06-01 – 2022-10-01
Classification: 10601
Homepage: https://www.infralife.se/activities/education-and-training/structural-biology-course/
Keywords:

Abstract

Integrative structural biology course InfraLife is preparing a course in integrative structural biology where we cover not only the basics of state-of-the-art structural biology techniques, but also how to combine the information to address a biological question. The course will take place in the autumn of 2022, Aug 22nd to Sept 2nd). What will the course cover? The two week course is a joint effort between the three large-scale research infrastructures SciLifeLab, MAX IV and ESS and additional related platforms. The aim is to give an overview of the structural biology available at the research infrastructures in Sweden. This course is an initiative to increase and broaden the user base for the large scale infrastructures in Sweden and strengthens the collaboration between life science stakeholders. The course will focus on understanding the sample requirements, the nature of structural information that can be obtained and how data from multiple structural biology methods can be combined using e.g. computational chemistry techniques. The course consists of lectures, key note speakers, modelling practicals and facility visits. In addition events allowing time for networking within the group of students, the teachers and other infrastructure personnel, contributing to an expanded professional network. Technologies/methods: • *Macromolecular X-ray and neutron crystallography • *Small angle X-ray and neutron scattering • *Cryo-electron microscopy • *Macromolecular nuclear magnetic resonance spectroscopy • *Structural mass spectrometry • *Modelling and Computational methods • *Biophysical characterization More specifically, the Berzelius system will be used to enable the students to perform practical´s (modelling and visualization) via PreSTO for different software such as: Scipion (Cryo-EM), Phenix and CCP4 (Macromolecular X-ray), CCPN-NMR.