Neuromorphometric signatures of diseases affecting the brain
||Neuromorphometric signatures of diseases affecting the brain|
||SNIC Small Storage|
||Rolf A Heckemann <firstname.lastname@example.org>|
||2022-02-01 – 2023-02-01|
This application for storage accompanies application SNIC 2022/5-40 for a medium compute allocation. The abstracts are identical apart from this paragraph.
Various conditions -- brain diseases as well as systemic diseases -- affect the human brain's structural configuration. For each condition, this raises the question whether quantifying such changes through morphometric analysis of brain images can yield biomarkers for predicting diagnosis, disease progression, and therapy response.
I have developed image segmentation software (MAPER and Pincram, featured in IVA's 100-list of 2020, https://www.iva.se/projekt/research2business/ivas-100-lista-2020/) that automatically determines morphometric quantities on magnetic resonance images of the brain.
With this application, I seek an allocation of computation time and storage to continue processing of images from several collaboration studies: ESOP (epilepsy surgery outcome prediction, PI Prof. Bertil Rydenhag, GU), CogThy (a controlled study of Graves' disease and its impact on the brain, PI Helena Filipsson-Nyström PhD, GU), Mega Donna Mega (a study of retinopathy in newborns; imaging arm led by Prof. Isabella Björkman-Burtscher, GU), Temporal lobe epilepsy at 7 Tesla (Prof. Isabella Björkman-Burtscher, GU), Automated brain tissue classification on CT images (Dr. Michael Schöll), Parkinson's disease (Rolf Heckemann). In addition, I am planning to process images of healthy volunteers from publicly available repositories (e.g. the Human Connectome Project) to obtain normative morphometric reference data.